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George Wilding Selected Research

2,2,5,7,8-pentamethyl-1-hydroxychroman

4/2016A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer.
8/2003Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells.

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George Wilding Research Topics

Disease

84Neoplasms (Cancer)
01/2022 - 03/2002
66Prostatic Neoplasms (Prostate Cancer)
01/2022 - 08/2002
23Renal Cell Carcinoma (Grawitz Tumor)
05/2016 - 04/2003
17Fatigue
05/2016 - 04/2003
16Carcinoma (Carcinomatosis)
01/2018 - 09/2002
12Neoplasm Metastasis (Metastasis)
12/2015 - 02/2004
9Disease Progression
05/2016 - 11/2002
8Neutropenia
05/2013 - 04/2003
6Nausea
04/2016 - 04/2004
6Diarrhea
08/2009 - 12/2002
4Pain (Aches)
03/2008 - 02/2004
3Adenocarcinoma
01/2022 - 11/2004
3Hand-Foot Syndrome
05/2016 - 08/2009
3Hypertension (High Blood Pressure)
05/2016 - 11/2007
3Thrombocytopenia (Thrombopenia)
09/2013 - 07/2004
3Lymphoma (Lymphomas)
02/2011 - 03/2002
3Transitional Cell Carcinoma
09/2009 - 11/2002
3Dehydration (Water Stress)
04/2009 - 11/2004
3Vomiting
12/2008 - 04/2004
2Exanthema (Rash)
05/2016 - 05/2006
2Embolism (Embolus)
05/2016 - 04/2009
2Vaccinia
09/2015 - 06/2004
2Fowlpox
09/2015 - 06/2004
2Fever (Fevers)
04/2014 - 12/2008
2Asthenia
12/2013 - 09/2008
2Hyponatremia
12/2011 - 02/2009
2Body Weight (Weight, Body)
03/2010 - 10/2003
2Stomach Neoplasms (Stomach Cancer)
06/2009 - 12/2002
2Febrile Neutropenia
05/2009 - 06/2007
2Hypokalemia
04/2009 - 08/2003
2Anorexia
02/2009 - 12/2008

Drug/Important Bio-Agent (IBA)

25AndrogensIBA
01/2021 - 11/2002
21Hormones (Hormone)IBA
01/2018 - 08/2002
12Pharmaceutical PreparationsIBA
04/2016 - 09/2002
11Sunitinib (Sutent)FDA Link
05/2016 - 01/2006
11Prostate-Specific Antigen (Semenogelase)IBA
09/2015 - 06/2004
10Paclitaxel (Taxol)FDA LinkGeneric
01/2018 - 04/2002
10Docetaxel (Taxotere)FDA Link
12/2013 - 06/2003
9Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2016 - 06/2003
9Biological ProductsIBA
04/2016 - 09/2002
9GemcitabineFDA Link
06/2012 - 04/2002
7Biomarkers (Surrogate Marker)IBA
01/2022 - 09/2002
7Androgen Receptors (Androgen Receptor)IBA
09/2015 - 11/2002
6Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
04/2016 - 01/2006
6Axitinib (AG 013736)IBA
04/2016 - 08/2005
6Doxorubicin (Adriamycin)FDA LinkGeneric
06/2012 - 04/2004
6Tyrosine Kinase InhibitorsIBA
04/2012 - 05/2006
5Vitamin DFDA LinkGeneric
12/2015 - 09/2002
5VaccinesIBA
09/2015 - 06/2004
5Bortezomib (Velcade)FDA Link
04/2014 - 05/2005
5VorinostatFDA Link
04/2014 - 04/2009
5Androgen Antagonists (Antiandrogens)IBA
04/2013 - 11/2002
5taxaneIBA
12/2012 - 08/2007
5Proteins (Proteins, Gene)FDA Link
06/2012 - 11/2002
5Interferon-alpha (Interferon Alfa)IBA
10/2011 - 04/2003
53-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA
02/2011 - 04/2008
5InterferonsIBA
02/2010 - 01/2003
4Sorafenib (BAY 43-9006)FDA Link
05/2016 - 09/2009
4Vitamin EFDA LinkGeneric
04/2016 - 08/2003
4AntioxidantsIBA
04/2016 - 08/2003
4Alkaline PhosphataseIBA
12/2015 - 04/2004
4Cisplatin (Platino)FDA LinkGeneric
04/2014 - 04/2004
42-MethoxyestradiolIBA
04/2012 - 09/2005
4Carboplatin (JM8)FDA LinkGeneric
09/2011 - 09/2002
3EstramustineFDA Link
01/2018 - 05/2006
3A-Form DNA (A-DNA)IBA
07/2014 - 12/2005
3prostatic acid phosphataseIBA
07/2014 - 12/2005
3Reactive Oxygen Species (Oxygen Radicals)IBA
05/2014 - 06/2008
3Dasatinib (BMS 354825)FDA Link
12/2013 - 12/2009
3Testosterone (Sustanon)FDA Link
07/2013 - 03/2008
3epothilone B (EPO906)IBA
06/2012 - 08/2007
3ixabepilone (BMS 247550)FDA Link
06/2012 - 08/2007
3CytokinesIBA
10/2011 - 11/2007
3PolyaminesIBA
08/2006 - 10/2003
3piritreximIBA
12/2005 - 11/2002
3Angiogenesis InhibitorsIBA
11/2005 - 06/2003
3Methotrexate (Mexate)FDA LinkGeneric
04/2004 - 11/2002
22,2,5,7,8-pentamethyl-1-hydroxychromanIBA
04/2016 - 08/2003
2Transaminases (Aminotransferases)IBA
04/2016 - 06/2007
2ProdrugsIBA
07/2015 - 06/2012
2DNA (Deoxyribonucleic Acid)IBA
07/2014 - 05/2005
2gossypol acetic acidIBA
04/2014 - 05/2009
2Zoledronic Acid (Zometa)FDA Link
12/2013 - 10/2011
2Prednisone (Sone)FDA LinkGeneric
12/2013 - 08/2007
2Phosphotransferases (Kinase)IBA
12/2013 - 11/2002
2src-Family KinasesIBA
12/2013 - 12/2009
2Lapatinib (GW572016)FDA Link
02/2013 - 11/2009
2Endothelin A ReceptorIBA
02/2011 - 12/2007
2Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
01/2011 - 06/2009
2Messenger RNA (mRNA)IBA
10/2010 - 06/2009
2Mitoxantrone (Novantrone)FDA LinkGeneric
02/2010 - 08/2007
2Tretinoin (Retinoic Acid)FDA LinkGeneric
02/2010 - 01/2003

Therapy/Procedure

36Therapeutics
01/2021 - 03/2002
14Castration
01/2018 - 03/2008
11Drug Therapy (Chemotherapy)
04/2014 - 04/2002
4Prostatectomy (Retropubic Prostatectomy)
01/2022 - 06/2006
4Drug Tapering
09/2008 - 02/2004
3Chemoprevention
04/2016 - 09/2006
3Immunotherapy
12/2015 - 12/2005
2Radiotherapy
07/2012 - 07/2004